Nature Communications (Jun 2019)
A synthesis strategy for tetracyclic terpenoids leads to agonists of ERβ
Abstract
Many natural-product like drugs have a tetracyclic terpenoid core. Here, the authors developed a synthesis of triterpene-like tetracyclic systems, and apply this method to the preparation of a number of enantiomeric compounds, two of which are very selective ligands for estrogen receptor beta