Nature Communications (Jun 2019)

A synthesis strategy for tetracyclic terpenoids leads to agonists of ERβ

  • Wan Shin Kim,
  • Zachary A. Shalit,
  • Sidney M. Nguyen,
  • Emmalie Schoepke,
  • Alan Eastman,
  • Thomas P. Burris,
  • Arti B. Gaur,
  • Glenn C. Micalizio

DOI
https://doi.org/10.1038/s41467-019-10415-6
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 10

Abstract

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Many natural-product like drugs have a tetracyclic terpenoid core. Here, the authors developed a synthesis of triterpene-like tetracyclic systems, and apply this method to the preparation of a number of enantiomeric compounds, two of which are very selective ligands for estrogen receptor beta