A One-Pot Divergent Sequence to Pyrazole and Quinoline Derivatives

Abstract

The hydroxy-pyrazole and 3-hydroxy-oxindole motifs have been utilised in several pharma and agrochemical leads but are distinctly underrepresented in the scientific literature due to the limited routes of preparation. We have developed a one-pot procedure for their synthesis starting from simple isatins. The method employs cheap and easy-to-handle building blocks and allows easy isolation.

Keywords

• pyrazole
• oxindole
• isatin
• Pfitzinger reaction
• Knorr pyrazole synthesis
• quinoline