Connecting the dots to find the missing link in oral carcinoma

Abstract

Transformation of an oral potentially malignant lesion to frank carcinoma can be considered a continuum due to the interplay of variables related to the host and environmental carcinogen exposure. Tumor populations should not be viewed as isolated cells but comprehended with the micro-environment. The seed and soil theory certainly needs revisiting.

Keywords

• Tumor microenvironment
• Stroma
• Oral carcinoma
• TIME