Вопросы современной педиатрии (Mar 2013)

Efficacy of usage of pneumococcal 7-valent vaccine in prophylaxis of pneumococcal infection in Novosibirsk children from risk groups

  • O. A. Beletskaya,
  • Yu.N. Gorbatykh,
  • A. N. Shmakov,
  • N. Yu. Ishalina,
  • T. Yu. Ivleva,
  • N. V. Kukhtinova

DOI
https://doi.org/10.15690/vsp.v12i2.630
Journal volume & issue
Vol. 12, no. 2
pp. 123 – 126

Abstract

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In order to prevent children morbidity and mortality 116 children aged from 6 months to 5 years from 2 risk groups (1 — with bronchial-pulmonary dysplasia and 2 — with congenital heart defects) were vaccinated with pneumococcal 7-valent conjugated vaccine in 2011 at the expense of municipal budget. Among 116 children from both groups 16 (14%) have had community-acquired pneumonia, which is 22 times higher than in general children population in this region. Dynamic 1-year follow-up showed significant decrease of community-acquired pneumonia prevalence in risk groups: from 16/116 (14%) to 1/75 (1%) (p =0,006). There were no cases of invasive pneumococcal infections among vaccinated children and in 87,5% of them the general morbidity decreased. The frequency of moderate general post-vaccinal reactions was 1,8%, topical reactions — 0,9%. There were no other side effects during post-vaccinal period. Thereafter, the vaccination against pneumococcal infection performed in Novosibirsk in children with risk of fatal complications showed high efficacy and safety of the used vaccine.

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