Biomimetic synthesis of active stilbenolignan derivatives by oxidative coupling and acid-catalyzed polymerization

Acta Pharmaceutica Sinica B. 2013;3(2):102-108 DOI 10.1016/j.apsb.2013.02.002


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Journal Title: Acta Pharmaceutica Sinica B

ISSN: 2211-3835 (Print); 2211-3843 (Online)

Publisher: Elsevier

Society/Institution: Insititute of Materia Medica, Chinese Academy of Medical Sciences and Chinese Pharmaceutical Association

LCC Subject Category: Medicine: Therapeutics. Pharmacology

Country of publisher: Netherlands

Language of fulltext: English

Full-text formats available: PDF, HTML



Chunsuo Yao
Mao Lin
Qingyun Yang


Blind peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 19 weeks


Abstract | Full Text

Two new stilbenolignans and one novel lactone stilbenolignan with a seven-membered ring were biomimetically synthesized by an oxidative coupling reaction and acid-catalyzed polymerization with either isorhapontigenin and ferulic acid or sinapinic acid, respectively, as the starting materials. The structures of the stilbenolignans were defined using spectral analysis and their mechanisms of formation are discussed. Anti-oxidant and anti-inflammatory activities of the novel stilbenolignans were tested, and the lactone stilbenolignan was observed to exhibit potent anti-oxidant activity.