Essential oils from wild Mentha longifolia subspecies typhoides and subspecies schimperi: Burn wound healing and antimicrobial candidates

Abstract

A comparative study was conducted on the essential oils (EOs) chemical composition from two subspecies of wild Mentha longifolia typhoides and schimperi, growing in Egypt, followed by biological investigation of EOs as antibacterial, antiquorum sensing and burn wound healing agents. Gas chromatography/mass spectrometry analysis of hydro-distillated EOs led to identification of 99 % of oil components. Schimperi oil revealed broadspectrum antibacterial activity with MIC values of 156 ∼ 625 μg/ml, lower than or close to ampicillin. The oil from typhoides exhibited a higher antiquorum-sensing effect. The potential of oils to heal burn injuries was assessed by applying the oils in ointment form to second-degree burn injury in mice for 21 days. Interestingly, skin healing activity in group treated with typhoides oil was more effective than that of the positive control (Silver sulfadiazine 1 %). These results suggest a promising candidate in the area of burn wound healing therapy.

Keywords

• Mentha longifolia
• Lamiaceae
• Essential oils
• Burn wound healing activity
• Antiquorum-sensing activity
• Antimicrobial activity