Transcriptomic signatures of NK cells suggest impaired responsiveness in HIV-1 infection and increased activity post-vaccination

Margaret C. Costanzo; Dohoon Kim; Matthew Creegan; Kerri G. Lal; Julie A. Ake; Jeffrey R. Currier; Hendrik Streeck; Merlin L. Robb; Nelson L. Michael; Diane L. Bolton; Nicholas J. Steers; Michael A. Eller

doi:10.1038/s41467-018-03618-w

Nature Communications (Mar 2018)

Transcriptomic signatures of NK cells suggest impaired responsiveness in HIV-1 infection and increased activity post-vaccination

Margaret C. Costanzo,
Dohoon Kim,
Matthew Creegan,
Kerri G. Lal,
Julie A. Ake,
Jeffrey R. Currier,
Hendrik Streeck,
Merlin L. Robb,
Nelson L. Michael,
Diane L. Bolton,
Nicholas J. Steers,
Michael A. Eller

Affiliations

Margaret C. Costanzo: U.S. Military HIV Research Program, Walter Reed Army Institute of Research
Dohoon Kim: U.S. Military HIV Research Program, Walter Reed Army Institute of Research
Matthew Creegan: U.S. Military HIV Research Program, Walter Reed Army Institute of Research
Kerri G. Lal: U.S. Military HIV Research Program, Walter Reed Army Institute of Research
Julie A. Ake: U.S. Military HIV Research Program, Walter Reed Army Institute of Research
Jeffrey R. Currier: Virus Diseases Branch, Walter Reed Army Institute of Research
Hendrik Streeck: U.S. Military HIV Research Program, Walter Reed Army Institute of Research
Merlin L. Robb: U.S. Military HIV Research Program, Walter Reed Army Institute of Research
Nelson L. Michael: U.S. Military HIV Research Program, Walter Reed Army Institute of Research
Diane L. Bolton: U.S. Military HIV Research Program, Walter Reed Army Institute of Research
Nicholas J. Steers: Division of Nephrology, Columbia University Medical Center
Michael A. Eller: U.S. Military HIV Research Program, Walter Reed Army Institute of Research

DOI: https://doi.org/10.1038/s41467-018-03618-w
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 16

Abstract

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Natural killer (NK) cells are important for eliminating cells under stress or infected by virus, and may have a function in anti-HIV immunity. Here the authors show that different NK-activating stimuli induce distinct transcriptional fingerprints in human NK cells that are analogous to changes caused by HIV vaccination or chronic infection.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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