Diabetology & Metabolic Syndrome (Jul 2012)

Fatty liver in men is associated with high serum levels of small, dense low-density lipoprotein cholesterol

  • Hosoyamada Kaori,
  • Uto Hirofumi,
  • Imamura Yasushi,
  • Hiramine Yasunari,
  • Toyokura Eriko,
  • Hidaka Yoshihiro,
  • Kuwahara Tomomi,
  • Kusano Ken,
  • Saito Kazuto,
  • Oketani Makoto,
  • Ido Akio,
  • Tsubouchi Hirohito

DOI
https://doi.org/10.1186/1758-5996-4-34
Journal volume & issue
Vol. 4, no. 1
p. 34

Abstract

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Abstract Aims Our study addressed potential associations between fatty liver and small, dense low-density lipoprotein cholesterol (sd-LDL-C) levels using a cross-sectional analysis. Methods We enrolled 476 male subjects. Serum sd-LDL-C concentrations were determined using precipitation assays. Results Subjects were divided into four groups based on triglyceride (TG) and LDL-C levels: A, TG Conclusions Fatty liver is a significant determinant of serum sd-LDL-C levels independent of the presence of obesity or hyperglycemia. Fatty liver may alter hepatic metabolism of TG and LDL-C, resulting in increased sd-LDL-C levels.

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