Frontiers in Cardiovascular Medicine (Jan 2021)
Biventricular Longitudinal Strain Predict Mortality in COVID-19 Patients
- Yuji Xie,
- Yuji Xie,
- Lufang Wang,
- Lufang Wang,
- Meng Li,
- Meng Li,
- He Li,
- He Li,
- Shuangshuang Zhu,
- Shuangshuang Zhu,
- Bin Wang,
- Bin Wang,
- Lin He,
- Lin He,
- Danqing Zhang,
- Danqing Zhang,
- Yongxing Zhang,
- Yongxing Zhang,
- Hongliang Yuan,
- Hongliang Yuan,
- Chun Wu,
- Chun Wu,
- Wei Sun,
- Wei Sun,
- Yanting Zhang,
- Yanting Zhang,
- Li Cui,
- Li Cui,
- Yu Cai,
- Yu Cai,
- Jing Wang,
- Jing Wang,
- Yali Yang,
- Yali Yang,
- Qing Lv,
- Qing Lv,
- Mingxing Xie,
- Mingxing Xie,
- Yuman Li,
- Yuman Li,
- Li Zhang,
- Li Zhang
Affiliations
- Yuji Xie
- Department of Ultrasound, Tongji Medical College, Union Hospital, Huazhong University of Science and Technology, Wuhan, China
- Yuji Xie
- Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China
- Lufang Wang
- Department of Ultrasound, Tongji Medical College, Union Hospital, Huazhong University of Science and Technology, Wuhan, China
- Lufang Wang
- Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China
- Meng Li
- Department of Ultrasound, Tongji Medical College, Union Hospital, Huazhong University of Science and Technology, Wuhan, China
- Meng Li
- Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China
- He Li
- Department of Ultrasound, Tongji Medical College, Union Hospital, Huazhong University of Science and Technology, Wuhan, China
- He Li
- Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China
- Shuangshuang Zhu
- Department of Ultrasound, Tongji Medical College, Union Hospital, Huazhong University of Science and Technology, Wuhan, China
- Shuangshuang Zhu
- Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China
- Bin Wang
- Department of Ultrasound, Tongji Medical College, Union Hospital, Huazhong University of Science and Technology, Wuhan, China
- Bin Wang
- Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China
- Lin He
- Department of Ultrasound, Tongji Medical College, Union Hospital, Huazhong University of Science and Technology, Wuhan, China
- Lin He
- Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China
- Danqing Zhang
- Department of Ultrasound, Tongji Medical College, Union Hospital, Huazhong University of Science and Technology, Wuhan, China
- Danqing Zhang
- Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China
- Yongxing Zhang
- Department of Ultrasound, Tongji Medical College, Union Hospital, Huazhong University of Science and Technology, Wuhan, China
- Yongxing Zhang
- Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China
- Hongliang Yuan
- Department of Ultrasound, Tongji Medical College, Union Hospital, Huazhong University of Science and Technology, Wuhan, China
- Hongliang Yuan
- Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China
- Chun Wu
- Department of Ultrasound, Tongji Medical College, Union Hospital, Huazhong University of Science and Technology, Wuhan, China
- Chun Wu
- Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China
- Wei Sun
- Department of Ultrasound, Tongji Medical College, Union Hospital, Huazhong University of Science and Technology, Wuhan, China
- Wei Sun
- Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China
- Yanting Zhang
- Department of Ultrasound, Tongji Medical College, Union Hospital, Huazhong University of Science and Technology, Wuhan, China
- Yanting Zhang
- Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China
- Li Cui
- Department of Ultrasound, Tongji Medical College, Union Hospital, Huazhong University of Science and Technology, Wuhan, China
- Li Cui
- Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China
- Yu Cai
- Department of Ultrasound, Tongji Medical College, Union Hospital, Huazhong University of Science and Technology, Wuhan, China
- Yu Cai
- Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China
- Jing Wang
- Department of Ultrasound, Tongji Medical College, Union Hospital, Huazhong University of Science and Technology, Wuhan, China
- Jing Wang
- Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China
- Yali Yang
- Department of Ultrasound, Tongji Medical College, Union Hospital, Huazhong University of Science and Technology, Wuhan, China
- Yali Yang
- Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China
- Qing Lv
- Department of Ultrasound, Tongji Medical College, Union Hospital, Huazhong University of Science and Technology, Wuhan, China
- Qing Lv
- Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China
- Mingxing Xie
- Department of Ultrasound, Tongji Medical College, Union Hospital, Huazhong University of Science and Technology, Wuhan, China
- Mingxing Xie
- Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China
- Yuman Li
- Department of Ultrasound, Tongji Medical College, Union Hospital, Huazhong University of Science and Technology, Wuhan, China
- Yuman Li
- Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China
- Li Zhang
- Department of Ultrasound, Tongji Medical College, Union Hospital, Huazhong University of Science and Technology, Wuhan, China
- Li Zhang
- Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China
- DOI
- https://doi.org/10.3389/fcvm.2020.632434
- Journal volume & issue
-
Vol. 7
Abstract
Background: Biventricular longitudinal strain has been recently demonstrated to be predictive of poor outcomes in various cardiovascular settings. Therefore, this study sought to investigate the prognostic implications of biventricular longitudinal strain in patients with coronavirus disease 2019 (COVID-19).Methods: We enrolled 132 consecutive patients with COVID-19. Left ventricular global longitudinal strain from the apical four-chamber views (LV GLS4CH) and right ventricular free wall longitudinal strain (RV FWLS) were obtained using two-dimensional speckle-tracking echocardiography.Results: Compared with patients without cardiac injury, those with cardiac injury had higher levels of coagulopathy and inflammatory biomarkers, higher incidence of complications, more mechanical ventilation therapy, and higher mortality. Patients with cardiac injury displayed decreased LV GLS4CH and RV FWLS, elevated pulmonary artery systolic pressure, and higher proportion of pericardial effusion. Higher biomarkers levels of inflammation and cardiac injury, and the presence of pericardial effusion were correlated with decreases in LV GLS4CH and RV FWLS. During hospitalization, 19 patients died. Compared with survivors, LV GLS4CH and RV FWLS were impaired in non-survivors. At a 3-month follow-up after discharge, significant improvements were observed in LV GLS4CH and RV FWLS. Multivariate Cox analysis revealed that LV GLS4CH [hazard ratio: 1.41; 95% confidence interval [CI]: 1.08 to 1.84; P = 0.011] and RV FWLS (HR: 1.29; 95% CI: 1.09–1.52; P = 0.003) were independent predictors of higher mortality in patients with COVID-19.Conclusions: LV GLS4CH and RV FWLS are independent and strong predictors of higher mortality in COVID-19 patients and can track improvement during the convalescent phase of their illness. Therefore, biventricular longitudinal strain may be crucial for risk stratification and serial follow-up in patients with COVID-19.
Keywords
- COVID-19
- speckle tracking echocardiography
- strain
- left ventricular function
- right ventricular function