Nature Communications (Dec 2021)
A predominant enhancer co-amplified with the SOX2 oncogene is necessary and sufficient for its expression in squamous cancer
- Yanli Liu,
- Zhong Wu,
- Jin Zhou,
- Dinesh K. A. Ramadurai,
- Katelyn L. Mortenson,
- Estrella Aguilera-Jimenez,
- Yifei Yan,
- Xiaojun Yang,
- Alison M. Taylor,
- Katherine E. Varley,
- Jason Gertz,
- Peter S. Choi,
- Andrew D. Cherniack,
- Xingdong Chen,
- Adam J. Bass,
- Swneke D. Bailey,
- Xiaoyang Zhang
Affiliations
- Yanli Liu
- State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University
- Zhong Wu
- Department of Surgery, West China Hospital, Sichuan University
- Jin Zhou
- Department of Surgery, West China Hospital, Sichuan University
- Dinesh K. A. Ramadurai
- Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah
- Katelyn L. Mortenson
- Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah
- Estrella Aguilera-Jimenez
- Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah
- Yifei Yan
- Cancer Research Program, Research Institute of the McGill University Health Centre
- Xiaojun Yang
- College of Animal Science and Technology, Northwest Agriculture and Forestry University
- Alison M. Taylor
- Department of Pathology and Cell Biology, Herbert Irving Comprehensive Cancer Center, Columbia University
- Katherine E. Varley
- Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah
- Jason Gertz
- Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah
- Peter S. Choi
- Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania
- Andrew D. Cherniack
- Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School
- Xingdong Chen
- State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University
- Adam J. Bass
- Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School
- Swneke D. Bailey
- Cancer Research Program, Research Institute of the McGill University Health Centre
- Xiaoyang Zhang
- State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University
- DOI
- https://doi.org/10.1038/s41467-021-27055-4
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
SOX2 amplification and overexpression represents a hallmark of squamous cancers with distinct distribution of chromatin accessible regions depending on cancer type. Here, the authors identify a single enhancer e1 that predominantly drives SOX2 expression in squamous cancer.
