Single-cell transcriptome analysis reveals cellular heterogeneity in mouse intra- and extra articular ligaments

Kyota Ishibashi; Kentaro Ikegami; Takashi Shimbo; Eiji Sasaki; Tomomi Kitayama; Yuzuru Nakamura; Takahiro Tsushima; Yasuyuki Ishibashi; Katsuto Tamai

doi:10.1038/s42003-022-04196-w

Communications Biology (Nov 2022)

Single-cell transcriptome analysis reveals cellular heterogeneity in mouse intra- and extra articular ligaments

Kyota Ishibashi,
Kentaro Ikegami,
Takashi Shimbo,
Eiji Sasaki,
Tomomi Kitayama,
Yuzuru Nakamura,
Takahiro Tsushima,
Yasuyuki Ishibashi,
Katsuto Tamai

Affiliations

Kyota Ishibashi: Department of Orthopaedic Surgery, Hirosaki University Graduate School of Medicine
Kentaro Ikegami: StemRIM Inc.
Takashi Shimbo: Department of Stem Cell Therapy Science, Graduate School of Medicine, Osaka University
Eiji Sasaki: Department of Orthopaedic Surgery, Hirosaki University Graduate School of Medicine
Tomomi Kitayama: Department of Stem Cell Therapy Science, Graduate School of Medicine, Osaka University
Yuzuru Nakamura: Department of Orthopaedic Surgery, Hirosaki University Graduate School of Medicine
Takahiro Tsushima: Department of Orthopaedic Surgery, Hirosaki University Graduate School of Medicine
Yasuyuki Ishibashi: Department of Orthopaedic Surgery, Hirosaki University Graduate School of Medicine
Katsuto Tamai: Department of Stem Cell Therapy Science, Graduate School of Medicine, Osaka University

DOI: https://doi.org/10.1038/s42003-022-04196-w
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 12

Abstract

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Cell heterogeneity in the mouse anterior cruciate ligament (ACL) and medial collateral ligament (MCL) is demonstrated using single-cell analysis with three types of fibroblasts identified, expressing Col14a1, Col12a1, or Col22a1.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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