Bio prospecting of Aloe barbadensis miller (Aloe vera) for silver nanoparticles against breast cancer: A review

Abstract

Silver nanoparticles (AgNPs) are gaining substantial importance in the fields of biotechnology and medicine. Its composites are metal oxides, silicates, polymers, graphene, fibers, dendrimers, etc. The greenly synthesized AgNPs possess advantages over conventional AgNPs in the form of fewer chemical reagents and a low temperature and pressure for synthesis. The anticancer efficacy of AgNPs is attributed to a number of variables, including size, shape, surface-to-volume ratio, etc. There are several ways to make SNPs, but the green synthesis of AgNPs, which uses harmless chemicals and natural reagents, has gained significant interest and value. In this review, a comprehensive range of topics related to silver nanoparticles, the environmentally friendly method of producing them from plants such as Aloe barbadensis miller (aloe vera), which have a vast medicinal uses, and their anticancer effectiveness against breast cancer cells are discussed. The synthesized AgNPs are characterized via a range of methods, for instance, Fourier Transform Infrared Spectroscopy (FTIR), UV–visible spectroscopy, Transmission Electron Microscopy (TEM), Scanning Electron Microscopy (SEM), Atomic Force Microscopy (AFM), and X-ray Diffraction (XRD). This review study includes an investigation into the stability of produced nanoparticles, the wide range of nanoparticle forms, the many techniques used in the conglomeration of nanoparticles, and comparison methods emphasizing the benefits of green synthesis relative to traditional techniques. Furthermore, the discussion explores the chemical and structural makeup of nanoparticles.

Keywords

• Silver nanoparticles
• Biological synthesis
• Anticancer activity
• Aloe barbadensis miller
• Breast cancer cells