Complexin-1 regulated assembly of single neuronal SNARE complex revealed by single-molecule optical tweezers

Tongrui Hao; Nan Feng; Fan Gong; Yang Yu; Jiaquan Liu; Yu-Xuan Ren

doi:10.1038/s42003-023-04506-w

Communications Biology (Feb 2023)

Complexin-1 regulated assembly of single neuronal SNARE complex revealed by single-molecule optical tweezers

Tongrui Hao,
Nan Feng,
Fan Gong,
Yang Yu,
Jiaquan Liu,
Yu-Xuan Ren

Affiliations

Tongrui Hao: State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Science
Nan Feng: State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Science
Fan Gong: National Facility for Protein Science in Shanghai, Zhangjiang Lab, Shanghai Advanced Research Institute, Chinese Academy of Sciences
Yang Yu: National Facility for Protein Science in Shanghai, Zhangjiang Lab, Shanghai Advanced Research Institute, Chinese Academy of Sciences
Jiaquan Liu: State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Science
Yu-Xuan Ren: Institute for Translational Brain Research, Shanghai Medical College, Fudan University

DOI: https://doi.org/10.1038/s42003-023-04506-w
Journal volume & issue: Vol. 6, no. 1
pp. 1 – 12

Abstract

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The use of single-molecule optical tweezers shows that complexin-1 shapes the assembly of the Synaptic-soluble N-ethylmaleimide-sensitive factor Attachment Receptor by multiple domains’ coordination.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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