Nature Communications (Apr 2016)
Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation
- Alexander Gusev,
- Huwenbo Shi,
- Gleb Kichaev,
- Mark Pomerantz,
- Fugen Li,
- Henry W. Long,
- Sue A. Ingles,
- Rick A. Kittles,
- Sara S. Strom,
- Benjamin A. Rybicki,
- Barbara Nemesure,
- William B. Isaacs,
- Wei Zheng,
- Curtis A. Pettaway,
- Edward D. Yeboah,
- Yao Tettey,
- Richard B. Biritwum,
- Andrew A. Adjei,
- Evelyn Tay,
- Ann Truelove,
- Shelley Niwa,
- Anand P. Chokkalingam,
- Esther M. John,
- Adam B. Murphy,
- Lisa B. Signorello,
- John Carpten,
- M. Cristina Leske,
- Suh-Yuh Wu,
- Anslem J. M. Hennis,
- Christine Neslund-Dudas,
- Ann W. Hsing,
- Lisa Chu,
- Phyllis J. Goodman,
- Eric A. Klein,
- John S. Witte,
- Graham Casey,
- Sam Kaggwa,
- Michael B. Cook,
- Daniel O. Stram,
- William J. Blot,
- Rosalind A. Eeles,
- Douglas Easton,
- ZSofia Kote-Jarai,
- Ali Amin Al Olama,
- Sara Benlloch,
- Kenneth Muir,
- Graham G. Giles,
- Melissa C. Southey,
- Liesel M. Fitzgerald,
- Henrik Gronberg,
- Fredrik Wiklund,
- Markus Aly,
- Brian E. Henderson,
- Johanna Schleutker,
- Tiina Wahlfors,
- Teuvo L. J. Tammela,
- Børge G. Nordestgaard,
- Tim J. Key,
- Ruth C. Travis,
- David E. Neal,
- Jenny L. Donovan,
- Freddie C. Hamdy,
- Paul Pharoah,
- Nora Pashayan,
- Kay-Tee Khaw,
- Janet L. Stanford,
- Stephen N. Thibodeau,
- Shannon K. McDonnell,
- Daniel J. Schaid,
- Christiane Maier,
- Walther Vogel,
- Manuel Luedeke,
- Kathleen Herkommer,
- Adam S. Kibel,
- Cezary Cybulski,
- Dominika Wokolorczyk,
- Wojciech Kluzniak,
- Lisa Cannon-Albright,
- Craig Teerlink,
- Hermann Brenner,
- Aida K. Dieffenbach,
- Volker Arndt,
- Jong Y. Park,
- Thomas A. Sellers,
- Hui-Yi Lin,
- Chavdar Slavov,
- Radka Kaneva,
- Vanio Mitev,
- Jyotsna Batra,
- Amanda Spurdle,
- Judith A. Clements,
- Manuel R. Teixeira,
- Hardev Pandha,
- Agnieszka Michael,
- Paula Paulo,
- Sofia Maia,
- Andrzej Kierzek,
- The PRACTICAL consortium,
- David V. Conti,
- Demetrius Albanes,
- Christine Berg,
- Sonja I. Berndt,
- Daniele Campa,
- E. David Crawford,
- W. Ryan Diver,
- Susan M. Gapstur,
- J. Michael Gaziano,
- Edward Giovannucci,
- Robert Hoover,
- David J. Hunter,
- Mattias Johansson,
- Peter Kraft,
- Loic Le Marchand,
- Sara Lindström,
- Carmen Navarro,
- Kim Overvad,
- Elio Riboli,
- Afshan Siddiq,
- Victoria L. Stevens,
- Dimitrios Trichopoulos,
- Paolo Vineis,
- Meredith Yeager,
- Gosia Trynka,
- Soumya Raychaudhuri,
- Frederick R. Schumacher,
- Alkes L. Price,
- Matthew L. Freedman,
- Christopher A. Haiman,
- Bogdan Pasaniuc
Affiliations
- Alexander Gusev
- Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health
- Huwenbo Shi
- Bioinformatics Interdepartmental Program, University of California Los Angeles
- Gleb Kichaev
- Bioinformatics Interdepartmental Program, University of California Los Angeles
- Mark Pomerantz
- Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School
- Fugen Li
- Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute
- Henry W. Long
- Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School
- Sue A. Ingles
- Department of Preventative Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center
- Rick A. Kittles
- University of Arizona College of Medicine and University of Arizona Cancer Center
- Sara S. Strom
- Department of Epidemiology, University of Texas M.D. Anderson Cancer Center
- Benjamin A. Rybicki
- Department of Public Health Sciences, Henry Ford Hospital
- Barbara Nemesure
- Department of Preventive Medicine, Stony Brook University
- William B. Isaacs
- James Buchanan Brady Urological Institute, Johns Hopkins Hospital and Medical Institution
- Wei Zheng
- Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine
- Curtis A. Pettaway
- Department of Urology, University of Texas M.D. Anderson Cancer Center
- Edward D. Yeboah
- Korle Bu Teaching Hospital
- Yao Tettey
- Korle Bu Teaching Hospital
- Richard B. Biritwum
- Korle Bu Teaching Hospital
- Andrew A. Adjei
- Korle Bu Teaching Hospital
- Evelyn Tay
- Korle Bu Teaching Hospital
- Ann Truelove
- Westat
- Shelley Niwa
- Westat
- Anand P. Chokkalingam
- School of Public Health, University of California
- Esther M. John
- Cancer Prevention Institute of California
- Adam B. Murphy
- Department of Urology, Northwestern University
- Lisa B. Signorello
- Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health
- John Carpten
- The Translational Genomics Research Institute
- M. Cristina Leske
- Department of Preventive Medicine, Stony Brook University
- Suh-Yuh Wu
- Department of Preventive Medicine, Stony Brook University
- Anslem J. M. Hennis
- Department of Preventive Medicine, Stony Brook University
- Christine Neslund-Dudas
- Department of Public Health Sciences, Henry Ford Hospital
- Ann W. Hsing
- Cancer Prevention Institute of California
- Lisa Chu
- Cancer Prevention Institute of California
- Phyllis J. Goodman
- SWOG Statistical Center, Fred Hutchinson Cancer Research Center
- Eric A. Klein
- Glickman Urological & Kidney Institute, Cleveland Clinic
- John S. Witte
- Department of Epidemiology and Biostatistics, University of California, San Francisco
- Graham Casey
- Department of Preventative Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center
- Sam Kaggwa
- Department of Surgery, Makerere University College of Health Sciences
- Michael B. Cook
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Daniel O. Stram
- Department of Preventative Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center
- William J. Blot
- Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine
- Rosalind A. Eeles
- The Institute of Cancer Research
- Douglas Easton
- Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Laboratory
- ZSofia Kote-Jarai
- The Institute of Cancer Research
- Ali Amin Al Olama
- Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Laboratory
- Sara Benlloch
- Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Laboratory
- Kenneth Muir
- Institute of Population Health, University of Manchester
- Graham G. Giles
- Cancer Epidemiology Centre, The Cancer Council Victoria
- Melissa C. Southey
- Department of Pathology, Genetic Epidemiology Laboratory, The University of Melbourne
- Liesel M. Fitzgerald
- Cancer Epidemiology Centre, The Cancer Council Victoria
- Henrik Gronberg
- Department of Medical Epidemiology and Biostatistics, Karolinska Institute
- Fredrik Wiklund
- Department of Medical Epidemiology and Biostatistics, Karolinska Institute
- Markus Aly
- Department of Medical Epidemiology and Biostatistics, Karolinska Institute
- Brian E. Henderson
- Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center
- Johanna Schleutker
- Department of Medical Biochemistry and Genetics Institute of Biomedicine Kiinamyllynkatu 10, University of Turku
- Tiina Wahlfors
- BioMediTech, University of Tampere and FimLab Laboratories
- Teuvo L. J. Tammela
- Department of Urology, Tampere University Hospital and Medical School, University of Tampere
- Børge G. Nordestgaard
- Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital
- Tim J. Key
- Nuffield Department of Population Health, Cancer Epidemiology
- Ruth C. Travis
- Nuffield Department of Population Health, Cancer Epidemiology
- David E. Neal
- Department of Oncology, University of Cambridge, Addenbrooke's Hospital
- Jenny L. Donovan
- School of Social and Community Medicine, University of Bristol, Canynge Hall
- Freddie C. Hamdy
- Department of Public Health, Section for Epidemiology, Aarhus University
- Paul Pharoah
- Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Laboratory
- Nora Pashayan
- Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Laboratory
- Kay-Tee Khaw
- Clinical Gerontology Unit, University of Cambridge
- Janet L. Stanford
- Division of Public Health Sciences, Fred Hutchinson Cancer Research Center
- Stephen N. Thibodeau
- Mayo Clinic
- Shannon K. McDonnell
- Mayo Clinic
- Daniel J. Schaid
- Mayo Clinic
- Christiane Maier
- Institute of Human Genetics, University Hospital Ulm
- Walther Vogel
- Institute of Human Genetics, University Hospital Ulm
- Manuel Luedeke
- Department of Urology, University Hospital Ulm
- Kathleen Herkommer
- Department of Urology, Klinikum rechts der Isar der Technischen Universitaet Muenchen
- Adam S. Kibel
- Division of Urologic Surgery, Brigham and Womens Hospital, Dana-Farber Cancer Institute
- Cezary Cybulski
- Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University
- Dominika Wokolorczyk
- Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University
- Wojciech Kluzniak
- Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University
- Lisa Cannon-Albright
- Division of Genetic Epidemiology, Department of Medicine, University of Utah School of Medicine
- Craig Teerlink
- Division of Genetic Epidemiology, Department of Medicine, University of Utah School of Medicine
- Hermann Brenner
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ)
- Aida K. Dieffenbach
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ)
- Volker Arndt
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ)
- Jong Y. Park
- Department of Cancer Epidemiology, Moffitt Cancer Center
- Thomas A. Sellers
- Department of Cancer Epidemiology, Moffitt Cancer Center
- Hui-Yi Lin
- Biostatistics Program, Moffitt Cancer Center
- Chavdar Slavov
- Department of Urology and Alexandrovska University Hospital, Medical University
- Radka Kaneva
- Department of Medical Chemistry and Biochemistry, Molecular Medicine Center, Medical University
- Vanio Mitev
- Department of Medical Chemistry and Biochemistry, Molecular Medicine Center, Medical University
- Jyotsna Batra
- Australian Prostate Cancer Research Centre-Qld, Institute of Health and Biomedical Innovation and School of Biomedical Science, Queensland University of Technology
- Amanda Spurdle
- Molecular Cancer Epidemiology Laboratory, Queensland Institute of Medical Research
- Judith A. Clements
- Australian Prostate Cancer Research Centre-Qld, Institute of Health and Biomedical Innovation and School of Biomedical Science, Queensland University of Technology
- Manuel R. Teixeira
- Department of Genetics, Portuguese Oncology Institute
- Hardev Pandha
- The University of Surrey
- Agnieszka Michael
- The University of Surrey
- Paula Paulo
- Department of Genetics, Portuguese Oncology Institute
- Sofia Maia
- Department of Genetics, Portuguese Oncology Institute
- Andrzej Kierzek
- The University of Surrey
- The PRACTICAL consortium
- David V. Conti
- Department of Preventive Medicine, Norris Cancer Center, University of Southern California Keck School of Medicine
- Demetrius Albanes
- Division of Cancer Epidemiology and Genetics, Nutritional Epidemiology Branch, National Cancer Institute, US National Institute of Health
- Christine Berg
- Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins Medicine
- Sonja I. Berndt
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Daniele Campa
- Genomic Epidemiology Group, German Cancer Research Center (DKFZ)
- E. David Crawford
- Urologic Oncology, University of Colorado at Denver Health Sciences Center
- W. Ryan Diver
- Epidemiology Research Program, American Cancer Society
- Susan M. Gapstur
- Epidemiology Research Program, American Cancer Society
- J. Michael Gaziano
- Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health
- Edward Giovannucci
- Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health
- Robert Hoover
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- David J. Hunter
- Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health
- Mattias Johansson
- International Agency for Research on Cancer
- Peter Kraft
- Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health
- Loic Le Marchand
- Epidemiology Program, University of Hawaii Cancer Center
- Sara Lindström
- Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health
- Carmen Navarro
- Department of Epidemiology, Regional Health Authority
- Kim Overvad
- Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins Medicine
- Elio Riboli
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London
- Afshan Siddiq
- Department of Genomics of Common Disease, School of Public Health, Imperial College London
- Victoria L. Stevens
- Epidemiology Research Program, American Cancer Society
- Dimitrios Trichopoulos
- Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health
- Paolo Vineis
- HuGeF Foundation
- Meredith Yeager
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Gosia Trynka
- Divisions of Genetics and Rheumatology, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School
- Soumya Raychaudhuri
- Broad Institute of Harvard and MIT
- Frederick R. Schumacher
- Department of Preventive Medicine, Norris Cancer Center, University of Southern California Keck School of Medicine
- Alkes L. Price
- Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health
- Matthew L. Freedman
- Broad Institute of Harvard and MIT
- Christopher A. Haiman
- Department of Preventive Medicine, Norris Cancer Center, University of Southern California Keck School of Medicine
- Bogdan Pasaniuc
- Bioinformatics Interdepartmental Program, University of California Los Angeles
- DOI
- https://doi.org/10.1038/ncomms10979
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 13
Abstract
Over one hundred loci have been identified to be associated with the familial risk of prostate cancer but the functional effects are poorly understood. Here the authors use single-nucleotide variant and epigentic data to show an underlying genetic architecture marked by histone modification.
