Mechanistic insights into chromatin targeting by leukemic NUP98-PHF23 fusion

Yi Zhang; Yiran Guo; Sheryl M. Gough; Jinyong Zhang; Kendra R. Vann; Kuai Li; Ling Cai; Xiaobing Shi; Peter D. Aplan; Gang Greg Wang; Tatiana G. Kutateladze

doi:10.1038/s41467-020-17098-4

Nature Communications (Jul 2020)

Mechanistic insights into chromatin targeting by leukemic NUP98-PHF23 fusion

Yi Zhang,
Yiran Guo,
Sheryl M. Gough,
Jinyong Zhang,
Kendra R. Vann,
Kuai Li,
Ling Cai,
Xiaobing Shi,
Peter D. Aplan,
Gang Greg Wang,
Tatiana G. Kutateladze

Affiliations

Yi Zhang: Department of Pharmacology, University of Colorado School of Medicine
Yiran Guo: Department of Biochemistry and Biophysics, Curriculum in Genetics and Molecular Biology, Lineberger Comprehensive Cancer Center, The University of North Carolina School of Medicine
Sheryl M. Gough: Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH
Jinyong Zhang: Department of Pharmacology, University of Colorado School of Medicine
Kendra R. Vann: Department of Pharmacology, University of Colorado School of Medicine
Kuai Li: Center for Epigenetics, Van Andel Research Institute
Ling Cai: Department of Biochemistry and Biophysics, Curriculum in Genetics and Molecular Biology, Lineberger Comprehensive Cancer Center, The University of North Carolina School of Medicine
Xiaobing Shi: Center for Epigenetics, Van Andel Research Institute
Peter D. Aplan: Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH
Gang Greg Wang: Department of Biochemistry and Biophysics, Curriculum in Genetics and Molecular Biology, Lineberger Comprehensive Cancer Center, The University of North Carolina School of Medicine
Tatiana G. Kutateladze: Department of Pharmacology, University of Colorado School of Medicine

DOI: https://doi.org/10.1038/s41467-020-17098-4
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 10

Abstract

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Chromosomal NUP98-PHF23 translocation is associated with an aggressive form of AML. Here, the authors report the molecular mechanisms by which NUP98-PHF23 recognizes the histone mark H3K4me3 and provide evidence of a direct link between the association of NUP98-PHD finger chimeras with H3K4me3-rich regions and leukemic transformation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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