Prolonged intracellular accumulation of light-inducible nanoparticles in leukemia cells allows their remote activation

Abstract

Leukaemia cells resident in the bone marrow niche are often resistant to conventional therapies. In this study, the authors develop light-sensitive, polymeric, retinoic acid-containing nanoparticles that are able to modulate the differentiation of resistant leukaemia cells bothin vitro and in vivo.