PAX7 target genes are globally repressed in facioscapulohumeral muscular dystrophy skeletal muscle

Christopher R. S. Banerji; Maryna Panamarova; Husam Hebaishi; Robert B. White; Frédéric Relaix; Simone Severini; Peter S. Zammit

doi:10.1038/s41467-017-01200-4

Nature Communications (Dec 2017)

PAX7 target genes are globally repressed in facioscapulohumeral muscular dystrophy skeletal muscle

Christopher R. S. Banerji,
Maryna Panamarova,
Husam Hebaishi,
Robert B. White,
Frédéric Relaix,
Simone Severini,
Peter S. Zammit

Affiliations

Christopher R. S. Banerji: Randall Centre of Cell and Molecular Biophysics, New Hunt’s House, King’s College London, Guy’s Campus
Maryna Panamarova: Randall Centre of Cell and Molecular Biophysics, New Hunt’s House, King’s College London, Guy’s Campus
Husam Hebaishi: Randall Centre of Cell and Molecular Biophysics, New Hunt’s House, King’s College London, Guy’s Campus
Robert B. White: Randall Centre of Cell and Molecular Biophysics, New Hunt’s House, King’s College London, Guy’s Campus
Frédéric Relaix: Paris Est-Creteil University, IMRB U955
Simone Severini: Department of Computer Science, University College London
Peter S. Zammit: Randall Centre of Cell and Molecular Biophysics, New Hunt’s House, King’s College London, Guy’s Campus

DOI: https://doi.org/10.1038/s41467-017-01200-4
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 13

Abstract

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Facioscapulohumeral muscular dystrophy is a myopathy linked to ectopic expression of the DUX4 transcription factor. The authors show that the suppression of targets genes of the myogenesis regulator PAX7 is a signature of FSHD, and might explain oxidative stress sensitivity and epigenetic changes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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