Single particle cryo-EM structure of the outer hair cell motor protein prestin

Carmen Butan; Qiang Song; Jun-Ping Bai; Winston J. T. Tan; Dhasakumar Navaratnam; Joseph Santos-Sacchi

doi:10.1038/s41467-021-27915-z

Nature Communications (Jan 2022)

Single particle cryo-EM structure of the outer hair cell motor protein prestin

Carmen Butan,
Qiang Song,
Jun-Ping Bai,
Winston J. T. Tan,
Dhasakumar Navaratnam,
Joseph Santos-Sacchi

Affiliations

Carmen Butan: Department of Surgery (Otolaryngology), Yale University School of Medicine
Qiang Song: Department of Surgery (Otolaryngology), Yale University School of Medicine
Jun-Ping Bai: Department of Neurology, Yale University School of Medicine
Winston J. T. Tan: Department of Surgery (Otolaryngology), Yale University School of Medicine
Dhasakumar Navaratnam: Department of Surgery (Otolaryngology), Yale University School of Medicine
Joseph Santos-Sacchi: Department of Surgery (Otolaryngology), Yale University School of Medicine

DOI: https://doi.org/10.1038/s41467-021-27915-z
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 11

Abstract

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Prestin, expressed in outer hair cell (OHC), belongs to the Slc26 transporter family and functions as a voltage-driven motor that drives OHC electromotility. Here, the authors report cryo-EM structure and characterization of gerbil prestin, with insights into its mechanism of action.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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