Patologìâ (Aug 2020)
Interleukin and prostaglandin status of patients with shingles depending on the severity of the disease
Abstract
Aim. The aim of the work is to study the interleukin and prostaglandin status of patients with shingles depending on the severity of the disease. Materials and methods. We examined the blood of 27 patients with shingles, aged from 52 to 69 years, with 11 women (40.7 %) and 16 men (59.3 %) among them. Mild shingles was observed in 7 patients (25.9 %), moderate shingles was observed in 12 patients (44.4 %) and severe shingles was observed in 8 patients (29.6 %). The control group consisted of 12 practically healthy people (7 men and 5 women aged from 50 to 67 years old), who had not been ill with shingles before, but had suffered from chickenpox in childhood. Determination of the quantitative content of interleukins (IL), tumor necrosis factor α (TNFa), prostaglandins (PG), thromboxane (TXB2) and matrix metalloproteinase-8 (MMR-8) in blood serum was performed using a solid-phase enzyme immunoassay. Statistical processing of the study results was performed using the Mann-Whitney test and the program Statistica v. 10.0. Results. Clinical manifestation of shingles is accompanied by the increase of concentrations of cytokines (IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, TNFα), prostanoids (PGE2, PGF2α, 6KPGF1α, TXB2) and matrix proteinase-8 (MMR-8) in blood serum. The degree of change in interleukin and prostaglandin status depends on the severity of shingles, and it is the lowest in its mild course, and the highest in its severe course. In interleukin status of patients with shingles the degree of increased concentrations of proinflammatory cytokines (IL-1β, IL-6, IL-8, TNFα) prevails over the degrees of increasing of cytokines with anti-inflammatory properties (IL-2, IL-4, IL-10). In the acute period of shingles in prostaglandin status of patients, there is an imbalance in the PGE2/PGF2α and 6KPGF1α/TXB2 systems with a predominance of concentrations of PGE2 over PGF2α, and TXB2 over 6KPGF1α in the blood serum. Conclusions. The degree of violation of the interleukin and prostaglandin status of patients with shingles progressively increases as the severity of the disease increases.
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