Critical Care Explorations (May 2021)

Development and Content Validation of a Multidisciplinary Standardized Management Pathway for Hypoxemic Respiratory Failure and Acute Respiratory Distress Syndrome

  • Ken Kuljit S. Parhar, MD, MSc,
  • Karolina Zjadewicz, MN,
  • Gwen E. Knight, BA,
  • Andrea Soo, PhD,
  • Jamie M. Boyd, MSc,
  • Danny J. Zuege, MD, MSc,
  • Daniel J. Niven, MD, MSc, PhD,
  • Christopher J. Doig, MD, MSc,
  • Henry T. Stelfox, MD, PhD

DOI
https://doi.org/10.1097/CCE.0000000000000428
Journal volume & issue
Vol. 3, no. 5
p. e0428

Abstract

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Objectives:. Treatment of hypoxemic respiratory failure and acute respiratory distress syndrome is complex. Evidence-based therapies that can improve survival and guidelines advocating their use exist; however, implementation is inconsistent. Our objective was to develop and validate an evidence-based, stakeholder-informed standardized management pathway for hypoxemic respiratory failure and acute respiratory distress syndrome to improve adherence to best practice. Design:. A standardized management pathway was developed using a modified Delphi consensus process with a multidisciplinary group of ICU clinicians. The proposed pathway was externally validated with a survey involving multidisciplinary stakeholders and clinicians. Setting:. In-person meeting and web-based surveys of ICU clinicians from 17 adult ICUs in the province of Alberta, Canada. Intervention:. Not applicable. Measurements and Main Results:. The consensus panel was comprised of 30 ICU clinicians (4 nurses, 10 respiratory therapists, 15 intensivists, 1 nurse practitioner; median years of practice 17 [interquartile range, 13–21]). Ninety-one components were serially rated and revised over two rounds of online and one in-person review. The final pathway included 46 elements. For the validation survey, 692 responses (including 59% nurses, 33% respiratory therapists, 7% intensivists and 1% nurse practitioners) were received. Agreement of greater than 75% was achieved on 43 of 46 pathway elements. Conclusions:. A 46-element evidence-informed hypoxemic respiratory failure and acute respiratory distress syndrome standardized management pathway was developed and demonstrated to have content validity.