The clinical case of infertility treatment caused by male factor (globozoospermia type 1) by the intracytoplasmic morphologically normal sperm injection with activation of the oocytes by Ca2+-ionophore

Abstract

A case of infertility treatment in couple with a male factor, the severe form of teratozoospermia (total globozoospermia (type 1)) was presented. This pathology is extremely rare (0.1 % at andrological patients). Globozoospermia (type 1) is an insufficiently studied disease and is a severe disorder of spermatogenesis that leads to 100 % of male infertility. Assisted reproductive technologies with using of intracytoplasmic morphologically normal sperm injection and the activation of oocytes – by Ca2+-ionophore A23187 in a man with globozoospermia (type 1) helped in the treatment of infertility in matrimony. Pregnancy and childbirth proceeded favorably.

Keywords

• globozoospermia
• ca2+-ionophore
• in vitro fertilization
• intracytoplasmic sperm injection
• intracytoplasmic morphologically normal sperm injection
• pregnancy
• clinical case