Memorias do Instituto Oswaldo Cruz (Dec 1992)

Dengue 2 virus enhancement in asthmatic and non asthmatic individual

  • Maria G. Guzman,
  • Gustavo Kouri,
  • Maritza Soler,
  • Jose Bravo,
  • Adolfo Rodriguez de la Vega,
  • Susana Vazquez,
  • Mayra Mune

DOI
https://doi.org/10.1590/S0074-02761992000400016
Journal volume & issue
Vol. 87, no. 4
pp. 559 – 564

Abstract

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During the 1981 dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) Cuban epidemic, bronchial asthma (BA) was frequently found as a personal or family antecedent in dengue hemorragic fever patients. Considering that antibody dependent enhancement (ADE) plays an important role in the etiopathogenic mechanism of DHF/DSS, we decide to study the Dengue 2 virus (D2V) capability of replication in peripheral blood leukocytes (PBL) from asthmatic patients and healthy persons. In 90% of asthmatic patients and 53.8% of control group it was obtained PBL with a significant D2V enhancing activity (X² p < 0.01). Power enhancement was higher in asthmatic group. This is the first in vitro study relating BA and the dengue 2 virus immuno enhancement. The results obtained support the role of BA as a risk factor for DHF/DSS as already described on epidemiological data.

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