GSK3 suppression upregulates β-catenin and c-Myc to abrogate KRas-dependent tumors

Aslamuzzaman Kazi; Shengyan Xiang; Hua Yang; Daniel Delitto; José Trevino; Rays H. Y. Jiang; Muhammad Ayaz; Harshani R. Lawrence; Perry Kennedy; Saïd M. Sebti

doi:10.1038/s41467-018-07644-6

Nature Communications (Dec 2018)

GSK3 suppression upregulates β-catenin and c-Myc to abrogate KRas-dependent tumors

Aslamuzzaman Kazi,
Shengyan Xiang,
Hua Yang,
Daniel Delitto,
José Trevino,
Rays H. Y. Jiang,
Muhammad Ayaz,
Harshani R. Lawrence,
Perry Kennedy,
Saïd M. Sebti

Affiliations

Aslamuzzaman Kazi: Drug Discovery Department, H. Lee Moffitt Cancer Center and Research Institute
Shengyan Xiang: Drug Discovery Department, H. Lee Moffitt Cancer Center and Research Institute
Hua Yang: Drug Discovery Department, H. Lee Moffitt Cancer Center and Research Institute
Daniel Delitto: Department of Surgery, University of Florida
José Trevino: Department of Surgery, University of Florida
Rays H. Y. Jiang: Department of Global Health and Center for Drug Discovery and Innovation, University of South Florida
Muhammad Ayaz: Drug Discovery Department, H. Lee Moffitt Cancer Center and Research Institute
Harshani R. Lawrence: Drug Discovery Department, H. Lee Moffitt Cancer Center and Research Institute
Perry Kennedy: Drug Discovery Department, H. Lee Moffitt Cancer Center and Research Institute
Saïd M. Sebti: Drug Discovery Department, H. Lee Moffitt Cancer Center and Research Institute

DOI: https://doi.org/10.1038/s41467-018-07644-6
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 9

Abstract

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Direct targeting of mutant KRas is challenging and alternative approaches are needed. Here they show glycogen synthase kinase 3 (GSK3) to be required for the growth and survival of human mutant KRas-dependent tumors but dispensable for mutant KRas-independent tumors and show GSK3 inhibition to inhibit in vivo growth of Kras mutant patient-derived pancreatic tumors.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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