SOX11 and SOX4 drive the reactivation of an embryonic gene program during murine wound repair

Qi Miao; Matthew C. Hill; Fengju Chen; Qianxing Mo; Amy T. Ku; Carlos Ramos; Elisabeth Sock; Véronique Lefebvre; Hoang Nguyen

doi:10.1038/s41467-019-11880-9

Nature Communications (Sep 2019)

SOX11 and SOX4 drive the reactivation of an embryonic gene program during murine wound repair

Qi Miao,
Matthew C. Hill,
Fengju Chen,
Qianxing Mo,
Amy T. Ku,
Carlos Ramos,
Elisabeth Sock,
Véronique Lefebvre,
Hoang Nguyen

Affiliations

Qi Miao: Stem Cells and Regenerative Medicine Center, Baylor College of Medicine
Matthew C. Hill: Program in Developmental Biology, Baylor College of Medicine
Fengju Chen: Dan L. Duncan Cancer Center, Baylor College of Medicine
Qianxing Mo: Dan L. Duncan Cancer Center, Baylor College of Medicine
Amy T. Ku: Stem Cells and Regenerative Medicine Center, Baylor College of Medicine
Carlos Ramos: Stem Cells and Regenerative Medicine Center, Baylor College of Medicine
Elisabeth Sock: Institut für Biochemie, Emil-Fischer-Zentrum, Friedrich-Alexander-Universität Erlangen-Nürnberg
Véronique Lefebvre: Department of Surgery/Division of Orthopedic Surgery, Children’s Hospital of Philadelphia
Hoang Nguyen: Stem Cells and Regenerative Medicine Center, Baylor College of Medicine

DOI: https://doi.org/10.1038/s41467-019-11880-9
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 20

Abstract

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Wounding induces changes in cell identity but the mechanisms regulating this are unclear. Here, the authors show that Sox11/Sox4 expression in the leading edge of wounds converts murine epidermal cells to an embryonic-like state and facilitates repair.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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