Nature Communications (Feb 2019)

Rationally designed carbohydrate-occluded epitopes elicit HIV-1 Env-specific antibodies

  • Cheng Zhu,
  • Elena Dukhovlinova,
  • Olivia Council,
  • Lihua Ping,
  • Edgar M. Faison,
  • Shamit S. Prabhu,
  • E. Lake Potter,
  • Stephen L. Upton,
  • Guowei Yin,
  • James M. Fay,
  • Laura P. Kincer,
  • Ean Spielvogel,
  • Sharon L. Campbell,
  • S. Rahima Benhabbour,
  • Hengming Ke,
  • Ronald Swanstrom,
  • Nikolay V. Dokholyan

DOI
https://doi.org/10.1038/s41467-019-08876-w
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 10

Abstract

Read online

Areas of HIV envelope (Env) that aren’t covered by glycans are potential targets for antibodies. Here, the authors computationally design small protein mimics of four such epitopes and show that they can induce Env binding antibodies in rabbits.