Nature Communications (Oct 2019)

Phase separation of Polo-like kinase 4 by autoactivation and clustering drives centriole biogenesis

  • Jung-Eun Park,
  • Liang Zhang,
  • Jeong Kyu Bang,
  • Thorkell Andresson,
  • Frank DiMaio,
  • Kyung S. Lee

DOI
https://doi.org/10.1038/s41467-019-12619-2
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 19

Abstract

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Regulation of centriole duplication is essential for normal chromosome segregation and the maintenance of genomic stability, and Polo-like kinase 4 (Plk4) is a known regulator with unclear mechanisms. Here the authors show that Plk4 undergoes phase separation into an assembling body through autophosphorylation which drives centriole biogenesis.