Linchuang Gandanbing Zazhi (Oct 2016)

Roles of regulatory T cells and T-helper cells in hepatitis B virus-related liver diseases

  • ZHOU Yan,
  • JING Xiang,
  • ZHU Zhengyan

Journal volume & issue
Vol. 32, no. 10
pp. 1994 – 1997


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In recent years, the role of immune cells in hepatitis B virus (HBV)-related liver diseases has attracted more and more attention. This article reviews the roles of regulatory T cells (Treg) and T-helper cell type 17 (Th17) in the development, progression, and prognosis of HBV-related liver diseases, especially HBV-related liver fibrosis and liver failure, as well as hepatocellular carcinoma. It is pointed out that the dynamic changes of Treg and Th17 cells in different stages of HBV infection and their roles in hepatocellular carcinoma need further investigation, and future studies on the regulatory effects of various signaling pathways on Treg or Th17 cells are needed to provide a more precise direction for the treatment of HBV-related diseases.