Nature Communications (Feb 2021)
Evolution of immune responses to SARS-CoV-2 in mild-moderate COVID-19
- Adam K. Wheatley,
- Jennifer A. Juno,
- Jing J. Wang,
- Kevin J. Selva,
- Arnold Reynaldi,
- Hyon-Xhi Tan,
- Wen Shi Lee,
- Kathleen M. Wragg,
- Hannah G. Kelly,
- Robyn Esterbauer,
- Samantha K. Davis,
- Helen E. Kent,
- Francesca L. Mordant,
- Timothy E. Schlub,
- David L. Gordon,
- David S. Khoury,
- Kanta Subbarao,
- Deborah Cromer,
- Tom P. Gordon,
- Amy W. Chung,
- Miles P. Davenport,
- Stephen J. Kent
Affiliations
- Adam K. Wheatley
- Department of Microbiology and Immunology, University of Melbourne, at The Peter Doherty Institute for Infection and Immunity
- Jennifer A. Juno
- Department of Microbiology and Immunology, University of Melbourne, at The Peter Doherty Institute for Infection and Immunity
- Jing J. Wang
- Department of Immunology, College of Medicine and Public Health, Flinders University
- Kevin J. Selva
- Department of Microbiology and Immunology, University of Melbourne, at The Peter Doherty Institute for Infection and Immunity
- Arnold Reynaldi
- Kirby Institute, University of New South Wales
- Hyon-Xhi Tan
- Department of Microbiology and Immunology, University of Melbourne, at The Peter Doherty Institute for Infection and Immunity
- Wen Shi Lee
- Department of Microbiology and Immunology, University of Melbourne, at The Peter Doherty Institute for Infection and Immunity
- Kathleen M. Wragg
- Department of Microbiology and Immunology, University of Melbourne, at The Peter Doherty Institute for Infection and Immunity
- Hannah G. Kelly
- Department of Microbiology and Immunology, University of Melbourne, at The Peter Doherty Institute for Infection and Immunity
- Robyn Esterbauer
- Department of Microbiology and Immunology, University of Melbourne, at The Peter Doherty Institute for Infection and Immunity
- Samantha K. Davis
- Department of Microbiology and Immunology, University of Melbourne, at The Peter Doherty Institute for Infection and Immunity
- Helen E. Kent
- Department of Microbiology and Immunology, University of Melbourne, at The Peter Doherty Institute for Infection and Immunity
- Francesca L. Mordant
- Department of Microbiology and Immunology, University of Melbourne, at The Peter Doherty Institute for Infection and Immunity
- Timothy E. Schlub
- Kirby Institute, University of New South Wales
- David L. Gordon
- Department of Microbiology and Infectious Diseases, Flinders University and SA Pathology, Flinders Medical Centre
- David S. Khoury
- Kirby Institute, University of New South Wales
- Kanta Subbarao
- Department of Microbiology and Immunology, University of Melbourne, at The Peter Doherty Institute for Infection and Immunity
- Deborah Cromer
- Kirby Institute, University of New South Wales
- Tom P. Gordon
- Department of Immunology, College of Medicine and Public Health, Flinders University
- Amy W. Chung
- Department of Microbiology and Immunology, University of Melbourne, at The Peter Doherty Institute for Infection and Immunity
- Miles P. Davenport
- Kirby Institute, University of New South Wales
- Stephen J. Kent
- Department of Microbiology and Immunology, University of Melbourne, at The Peter Doherty Institute for Infection and Immunity
- DOI
- https://doi.org/10.1038/s41467-021-21444-5
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 11
Abstract
Longitudinal analyses are needed to show how the immune response to Sars-Cov-2 infection changes over time. Here, the authors use multiple strategies to profile the change in immune cell responses from patients with convalescent COVID-19 over the course of ~5 months, showing that although neutralizing antibody responses drop off after ~4 months, B cell immune responses strengthen.
