Data for induction of cytotoxic response by natural and novel quercetin glycosides
Alexis H. Haskins,
Cathy Su,
Anya Engen,
Victoria A. Salinas,
Junko Maeda,
Mitsuru Uesaka,
Yasushi Aizawa,
Takamitsu A Kato
Affiliations
Alexis H. Haskins
Department of Environmental & Radiological Health Sciences, Colorado State University, 1618 Campus Delivery, Fort Collins, CO 80523, USA
Cathy Su
Department of Environmental & Radiological Health Sciences, Colorado State University, 1618 Campus Delivery, Fort Collins, CO 80523, USA
Anya Engen
Department of Environmental & Radiological Health Sciences, Colorado State University, 1618 Campus Delivery, Fort Collins, CO 80523, USA
Victoria A. Salinas
Department of Environmental & Radiological Health Sciences, Colorado State University, 1618 Campus Delivery, Fort Collins, CO 80523, USA
Junko Maeda
Department of Environmental & Radiological Health Sciences, Colorado State University, 1618 Campus Delivery, Fort Collins, CO 80523, USA
Mitsuru Uesaka
Graduate School of Engineering, The University of Tokyo, Tokyo 113-8685, Japan
Yasushi Aizawa
Graduate School of Engineering, The University of Tokyo, Tokyo 113-8685, Japan; Research and Development Group, Toyo Sugar Refining Co. Ltd., Tokyo 103-0046, Japan
Takamitsu A Kato
Department of Environmental & Radiological Health Sciences, Colorado State University, 1618 Campus Delivery, Fort Collins, CO 80523, USA
The flavonoids quercetin, and its natural glycosides isoquercetin and rutin, are phytochemicals commonly consumed in plant-derived foods and used as a food beverage additive. Semi-synthetic maltooligosyl isoquercetin, monoglucosyl rutin and maltooligosyl rutin were developed by synthetic glycosylation to improve their water solubility for food and other applications. Using a system of Chinese hamster ovary (CHO) cells, this study examined the differences in cytotoxic responses induced by short and continuous exposure of natural and synthetic flavonoids. By assessing cell viability after short term exposure and clonogenicity with continuous exposure under various flavonoids, quercetin aglycone is confirmed to be the most cytotoxic flavonoids, and heavily glucosylated maltooligosyl rutin was the least cytotoxic. The other heavily glucosylated maltooligosyl isoquercetin showed intermediate cytotoxicity and similar toxicity as isoquercetin. Keywords: Cytotoxicity, Flavonoid, Quercetin, Isoquercetin, Rutin
