Visualizing Tetrahedral Oxyanion Bound in HIV‑1 Protease Using Neutrons: Implications for the Catalytic Mechanism and Drug Design
Mukesh Kumar,
Kalyaneswar Mandal,
Matthew P. Blakeley,
Troy Wymore,
Stephen B. H. Kent,
John M. Louis,
Amit Das,
Andrey Kovalevsky
Affiliations
Mukesh Kumar
Protein Crystallography Section, Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Mumbai, India
Kalyaneswar Mandal
Departments of Chemistry, and Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, University of Chicago, Chicago, Illinois, United States
Matthew P. Blakeley
Large Scale Structures Group, Institut Laue−Langevin, Grenoble, France
Troy Wymore
Department of Chemistry, University of Michigan, Ann Arbor, Michigan, United States
Stephen B. H. Kent
Departments of Chemistry, and Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, University of Chicago, Chicago, Illinois, United States
John M. Louis
Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, DHHS, Bethesda, Maryland, United States
Amit Das
Protein Crystallography Section, Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Mumbai, India
Andrey Kovalevsky
Neutron Scattering Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee, United States
