Visualizing Tetrahedral Oxyanion Bound in HIV‑1 Protease Using Neutrons: Implications for the Catalytic Mechanism and Drug Design

• Mukesh Kumar,
• Kalyaneswar Mandal,
• Matthew P. Blakeley,
• Troy Wymore,
• Stephen B. H. Kent,
• John M. Louis,
• Amit Das,
• Andrey Kovalevsky

Affiliations

Mukesh Kumar

Protein Crystallography Section, Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Mumbai, India

Kalyaneswar Mandal

Departments of Chemistry, and Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, University of Chicago, Chicago, Illinois, United States

Matthew P. Blakeley

Large Scale Structures Group, Institut Laue−Langevin, Grenoble, France

Troy Wymore

Department of Chemistry, University of Michigan, Ann Arbor, Michigan, United States

Stephen B. H. Kent

Departments of Chemistry, and Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, University of Chicago, Chicago, Illinois, United States

John M. Louis

Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, DHHS, Bethesda, Maryland, United States

Amit Das

Protein Crystallography Section, Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Mumbai, India

Andrey Kovalevsky

Neutron Scattering Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee, United States