Nature Communications (Mar 2021)

Inter- and intra-tumor heterogeneity of metastatic prostate cancer determined by digital spatial gene expression profiling

  • Lauren Brady,
  • Michelle Kriner,
  • Ilsa Coleman,
  • Colm Morrissey,
  • Martine Roudier,
  • Lawrence D. True,
  • Roman Gulati,
  • Stephen R. Plymate,
  • Zoey Zhou,
  • Brian Birditt,
  • Rhonda Meredith,
  • Gary Geiss,
  • Margaret Hoang,
  • Joseph Beechem,
  • Peter S. Nelson

DOI
https://doi.org/10.1038/s41467-021-21615-4
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 16

Abstract

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The inter- and intra-tumor heterogeneity of metastatic prostate cancer (mPC) is underexplored. Here the authors use Digital Spatial Profiling to study gene and protein expression heterogeneity in 27 mPC patients, finding variation in associated pathways and potential immunotherapy targets.