Treating Preeclampsia in the COVID-19 Era: Is Allopurinol Useful as an Adjuvant Therapy? A Case Report and Review of the Literature
Melinda-Ildiko Mitranovici,
Diana Maria Chiorean,
Maria Cezara Mureșan,
Corneliu-Florin Buicu,
Raluca Moraru,
Liviu Moraru,
Titiana Cornelia Cotoi,
Ovidiu Simion Cotoi,
Havva Serap Toru,
Adrian Apostol,
Sabin Gligore Turdean,
Ion Petre,
Claudiu Mărginean,
Ioan Emilian Oală,
Viviana Ivan,
Lucian Pușcașiu
Affiliations
Melinda-Ildiko Mitranovici
Department of Obstetrics and Gynecology, Emergency County Hospital Hunedoara, 14 Victoriei Street, 331057 Hunedoara, Romania
Diana Maria Chiorean
Department of Pathology, County Clinical Hospital of Targu Mures, 540072 Targu Mures, Romania
Maria Cezara Mureșan
Department of Obstetrics and Gynecology, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Sq., 300041 Timisoara, Romania
Corneliu-Florin Buicu
Public Health and Management Department, “George Emil Palade” University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540139 Targu Mures, Romania
Raluca Moraru
Faculty of Medicine, “George Emil Palade” University of Medicine, Pharmacy, Sciences and Technology, 540142 Targu Mures, Romania
Liviu Moraru
Department of Anatomy, “George Emil Palade” University of Medicine, Pharmacy, Sciences and Technology, 540142 Targu Mures, Romania
Titiana Cornelia Cotoi
Department of Pharmaceutical Technology, “George Emil Palade” University of Medicine, Pharmacy, Sciences and Technology, 540142 Targu Mures, Romania
Ovidiu Simion Cotoi
Department of Pathology, County Clinical Hospital of Targu Mures, 540072 Targu Mures, Romania
Havva Serap Toru
Department of Pathology, Akdeniz University School of Medicine, Antalya Pınarbaşı, Konyaaltı, Antalya 07070, Turkey
Adrian Apostol
Department of Cardiology, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Sq., 300041 Timisoara, Romania
Sabin Gligore Turdean
Department of Pathology, County Clinical Hospital of Targu Mures, 540072 Targu Mures, Romania
Ion Petre
Department of Medical Informatics and Biostatistics, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Sq., 300041 Timisoara, Romania
Claudiu Mărginean
Department of Obstetrics and Gynecology, “George Emil Palade” University of Medicine, Pharmacy, Sciences and Technology, 540142 Targu Mures, Romania
Ioan Emilian Oală
Department of Obstetrics and Gynecology, Emergency County Hospital Hunedoara, 14 Victoriei Street, 331057 Hunedoara, Romania
Viviana Ivan
Department of Obstetrics and Gynecology, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Sq., 300041 Timisoara, Romania
Lucian Pușcașiu
Department of Obstetrics and Gynecology, “George Emil Palade” University of Medicine, Pharmacy, Sciences and Technology, 540142 Targu Mures, Romania
Acute respiratory syndrome-related coronavirus 2, or SARS-CoV-2, mainly affects the vulnerable population, especially those with comorbidities, such as pregnant women. SARS-CoV-2 has been found to cause multiple manifestations, one of which is preeclampsia. In preeclampsia, uric acid is excessively produced in the ischemic placenta and is released into circulation by placental reperfusion. Another effect of uric acid is oxidative stress with the production of oxygen free radicals associated with severe preeclampsia and fetal hypoxia. In our case report, we present the situation of a 38-year-old pregnant woman who developed preeclampsia after infection with SARS-CoV-2 with rapid evolution and an increased level of uric acid. We discuss the option of Allopurinol treatment in the third trimester of pregnancy instead of premature birth, with excellent benefits for both the mother and newborn. Additional clinical correlations between antioxidant treatment with Allopurinol and placental findings are needed.
