Lipid-Polymeric Films: Composition, Production and Applications in Wound Healing and Skin Repair
Eliana B. Souto,
Cristiana M. P. Yoshida,
Gislaine R. Leonardi,
Amanda Cano,
Elena Sanchez-Lopez,
Aleksandra Zielinska,
César Viseras,
Patricia Severino,
Classius F. da Silva,
Raquel de M. Barbosa
Affiliations
Eliana B. Souto
CEB—Centre of Biological Engineering, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal
Cristiana M. P. Yoshida
Faculty of Pharmaceutical Sciences, Federal University of São Paulo, Rua São Nicolau, 210, Diadema, São Paulo 09913-030, Brazil
Gislaine R. Leonardi
Faculty of Pharmaceutical Sciences, State University of Campinas, Rua Cândido Portinari, 200—Cidade Universitária, Campinas 13083-871, Brazil
Amanda Cano
Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain
Elena Sanchez-Lopez
Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain
Aleksandra Zielinska
CEB—Centre of Biological Engineering, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal
César Viseras
Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Granada, Campus of Cartuja s/n, 18071 Granada, Spain
Patricia Severino
Institute of Technology and Research (ITP), Av. Murilo Dantas, 300, Aracaju 49010-390, Brazil
Classius F. da Silva
Faculty of Pharmaceutical Sciences, Federal University of São Paulo, Rua São Nicolau, 210, Diadema, São Paulo 09913-030, Brazil
Raquel de M. Barbosa
Laboratory of Drug Development, Department of Pharmacy, School of Pharmacy, Federal University of Rio Grande do Norte, Natal 59078-970, Brazil
The use of lipids in the composition of polymeric-based films for topical administration of bioactive ingredients is a recent research topic; while few products are commercially available, films containing lipids represent a strategic area for the development of new products. Some lipids are usually used in polymeric-based film formulations due to their plasticizing action, with a view to improving the mechanical properties of these films. On the other hand, many lipids have healing, antimicrobial, anti-inflammatory, anti-aging properties, among others, that make them even more interesting for application in the medical-pharmaceutical field. This manuscript discusses the production methods of these films both on a laboratory and at industrial scales, the properties of the developed biopolymers, and their advantages for the development of dermatologic and cosmetic products.
