Медицинская иммунология (Jul 2014)

FEATURES OF INTERRELATIONS BETWEEN IMMUNE STATUS INDICATORS AND AMOUNTS OF BLAST CELLS IN ACUTE LEUKEMIA

  • O. V. Smirnova,
  • A. А. Savchenko,
  • V. T. Manchouk

DOI
https://doi.org/10.15789/1563-0625-2011-1-49-54
Journal volume & issue
Vol. 13, no. 1
pp. 49 – 54

Abstract

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Аbstract. The purpose of study was to evaluate some characteristics of immune state in the patients with acute non-differentiated leukemia (ANLL) and acute lymphoblastic leukemia (ALL), and to detect interrelations between the features of immune state and their dependencies on disease stage and quantities of blast cells, using a neuronet modeling approach. A decrease in immune system reactivity was revealed in acute leukemia patients. At any ALL stage, a T-cell immunodeficiency is registered. A decrease of T lymphocyte amounts and reduction of CD4+:CD8+ ratio are associated with occurrence of ALL relapse. Increased contents of NK cells are a feature of ALL recurrence. T cell deficiency emerges during ANLL relapse and remission. Meanwhile, a combined immunodeficiency develops upon relapse of the disease, affecting both T and B systems of immune response. Exhaustion of NK cell contents is a characteristic feature of ANLL, thus potentially promoting progression and relapse of the disease. By means of a neuronet predictor, a significance of information for certain immune state parameters was assessed, by determining amounts of blast cells in bone marrow. It was found that a specific histogram of informativity is revealed for each group of the patients. A computer-based experiment was performed which proves the specificity of interrelations between the immune state indices in a neuroprediction model for ALL and ANLL. (Med. Immunol., 2011, vol. 13, N 1, pp 49-54)

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