Molecular Targets of Ferroptosis in Hepatocellular Carcinoma

Abstract

Hao Liao,1,2,* Juanyi Shi,1,2,* Kai Wen,1,2 Jianhong Lin,1,2 Qinghua Liu,1,2 Bingchao Shi,1,2 Yongcong Yan,1,2 Zhiyu Xiao1,2 1Department of Hepatobiliary Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, People’s Republic of China; 2Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yongcong Yan; Zhiyu XiaoDepartment of Hepatobiliary Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Yanjiang West Road #107, Guangzhou, 510120, People’s Republic of ChinaTel [phone]; [phone]Fax [phone]Email [email protected]; [email protected]: Ferroptosis is a special form of regulatory cell death caused by the accumulation of intracellular iron and lipid peroxidation. Here, we summarize the research progress on ferroptosis in hepatocellular carcinoma (HCC), trace the development of the concept of ferroptosis and its key regulatory factors, and discuss the application value of ferroptosis in the treatment of HCC from different perspectives. We believe that exploring the relationship between ferroptosis and HCC and clarifying the metabolism and expression of ferroptosis-specific genes and molecules will accelerate the development of novel ferroptosis-related molecules as HCC markers and therapeutic targets. We hope to provide a theoretical basis for better diagnosis and treatment to effectively improve the prognosis of patients with HCC.Keywords: hepatocellular carcinoma, ferroptosis, iron, regulatory cell death, lipid peroxidation, sorafenib

Keywords

• hepatocellular carcinoma
• ferroptosis
• iron
• regulatory cell death
• lipid peroxidation
• sorafenib