Nature Communications (Aug 2022)

Met1-specific motifs conserved in OTUB subfamily of green plants enable rice OTUB1 to hydrolyse Met1 ubiquitin chains

  • Lining Lu,
  • Xiaoguo Zhai,
  • Xiaolong Li,
  • Shuansuo Wang,
  • Lijun Zhang,
  • Luyang Wang,
  • Xi Jin,
  • Lujun Liang,
  • Zhiheng Deng,
  • Zichen Li,
  • Yanfeng Wang,
  • Xiangdong Fu,
  • Honggang Hu,
  • Jiawei Wang,
  • Ziqing Mei,
  • Zhengguo He,
  • Feng Wang

DOI
https://doi.org/10.1038/s41467-022-32364-3
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 14

Abstract

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Deubiquitinases (DUBs) targeting Met1-linked ubiquitin chains have important functions in mammals but are barely studied in plants. Here, the authors identify rice OTUB1 as a Met1-targeting DUB, characterize the structural determinants of this activity, and show that these features are conserved in green plants.