BMB Reports (Sep 2013)

Anti-wrinkle effect of bone morphogenetic protein receptor 1a-extracellular domain (BMPR1a-ECD)

  • Byung-Hak Yoon,
  • Yun-Hui Jeon,
  • Byunghee Hwang,
  • Hyuknam Kwon,
  • Senyon Choe,
  • Zungyoon Yang

DOI
https://doi.org/10.5483/BMBRep.2013.46.9.238
Journal volume & issue
Vol. 46, no. 9
pp. 465 – 470

Abstract

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Bone morphogenetic proteins (BMPs) have diverse andimportant roles in the proliferation and differentiation of adultstem cells in our tissues. Especially, BMPs are well known tobe the main inducers of bone formation, by facilitating bothproliferation and differentiation of bone stem cells.Interestingly, in skin stem cells, BMPs repress their proliferationbut are indispensable for the proper differentiation intoseveral lineages of skin cells. Here, we tested whether BMPantagonists have an effect on the prevention of wrinkleformation. For this study we used an in vivo wrinkle-inducedmouse model. As a positive control, retinoic acid, one of thetop anti-wrinkle effectors, showed a 44% improvementcompared to the non-treated control. Surprisingly, bonemorphogenetic protein receptor 1a extracellular domain(BMPR1a-ECD) exhibited an anti-wrinkle effect which was6-fold greater than that of retinoic acid. Our results indicatethat BMP antagonists will be good targets for skin or hairdiseases. [BMB Reports 2013; 46(9): 465-470]

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