Whole-genome plasma sequencing reveals focal amplifications as a driving force in metastatic prostate cancer

Peter Ulz; Jelena Belic; Ricarda Graf; Martina Auer; Ingrid Lafer; Katja Fischereder; Gerald Webersinke; Karl Pummer; Herbert Augustin; Martin Pichler; Gerald Hoefler; Thomas Bauernhofer; Jochen B. Geigl; Ellen Heitzer; Michael R. Speicher

doi:10.1038/ncomms12008

Nature Communications (Jun 2016)

Whole-genome plasma sequencing reveals focal amplifications as a driving force in metastatic prostate cancer

Peter Ulz,
Jelena Belic,
Ricarda Graf,
Martina Auer,
Ingrid Lafer,
Katja Fischereder,
Gerald Webersinke,
Karl Pummer,
Herbert Augustin,
Martin Pichler,
Gerald Hoefler,
Thomas Bauernhofer,
Jochen B. Geigl,
Ellen Heitzer,
Michael R. Speicher

Affiliations

Peter Ulz: Institute of Human Genetics, Medical University of Graz
Jelena Belic: Institute of Human Genetics, Medical University of Graz
Ricarda Graf: Institute of Human Genetics, Medical University of Graz
Martina Auer: Institute of Human Genetics, Medical University of Graz
Ingrid Lafer: Institute of Human Genetics, Medical University of Graz
Katja Fischereder: Department of Urology, Medical University of Graz
Gerald Webersinke: Department of Internal Medicine I, Hospital Barmherzige Schwestern Linz
Karl Pummer: Department of Urology, Medical University of Graz
Herbert Augustin: Department of Urology, Medical University of Graz
Martin Pichler: Department of Internal Medicine, Division of Oncology, Medical University of Graz
Gerald Hoefler: Institute of Pathology, Medical University of Graz
Thomas Bauernhofer: Department of Internal Medicine, Division of Oncology, Medical University of Graz
Jochen B. Geigl: Institute of Human Genetics, Medical University of Graz
Ellen Heitzer: Institute of Human Genetics, Medical University of Graz
Michael R. Speicher: Institute of Human Genetics, Medical University of Graz

DOI: https://doi.org/10.1038/ncomms12008
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 12

Abstract

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The genomic features of metastatic prostate cancer are beginning to be understood. Here, the authors performed whole genome sequencing of plasma samples from these patients and found a high plasticity of the cancer genomes with newly occurring focal amplifications as a driving force in progression.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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