Research progress of metabolomics in the diagnosis and treatment of severe injuries

Abstract

Metabolomics is a novel emerging technology recently applied in management of severe diseases and trauma, and has been widely used in gene analysis of disease metabolic disorders, clinical biomarker screening and disease diagnosis. This review comprehensively summarizes the latest research progress of the metabolomics in severe trauma and burns recently like traumatic brain injury(TBI), traumatic hemorrhagic shock, severe burns and so on. The paper elaborates the metabolomic technology which can quickly reflect the real-time metabolic changes of severely injured patients at different stages after injury, and uncovers new clinical biomarkers and potential drug targets of the patients with severe injuries thus improves the diagnosis and treatment strategies. Finally, we look forward to the current metabolomics research projects and tackling challenges on the burn-blast combined injuries, and the simultaneous development of multi-omics technology as well as artificial intelligence algorithms, which promotes the development of precision medicine.

Keywords

• metabolomics|trauma|burn|burn-blast combined injury