Haematologica (Feb 2008)

Reduced intensity conditioning allogeneic stem cell transplantation for adult patients with acute lymphoblastic leukemia: a retrospective study from the European Group for Blood and Marrow Transplantation

  • Mohamad Mohty,
  • Myriam Labopin,
  • Reza Tabrizzi,
  • Niklas Theorin,
  • Axel A Fauser,
  • Alessandro Rambaldi,
  • Johan Maertens,
  • Shimon Slavin,
  • Ignazio Majolino,
  • Arnon Nagler,
  • Didier Blaise,
  • Vanderson Rocha

DOI
https://doi.org/10.3324/haematol.11960
Journal volume & issue
Vol. 93, no. 2

Abstract

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This retrospective study reported the outcome of 97 adult acute lymphoblastic leukemia patients who received a reduced-intensity conditioning allogeneic stem cell transplantation. With a median follow-up of 2.8 years, two year overall-survival, leukemia-free survival and non-relapse mortality were significantly better in patients transplanted in first complete remission (CR1, 52±9%; 42±10%; and 18±7% respectively) compared with those transplanted in more advanced phase (p=0.003, p=0.002 and p=0.01 respectively). In multivariate analysis, disease status (CR1 vs. advanced; p=0.001) and chronic graft-vs-host disease (p=0.01) were associated with an improved overall-survival, suggesting that reduced-intensity conditioning allogeneic stem cell transplantation is feasible in patients with high risk lymphoblastic leukemia in remission at transplantation.