中枢胰岛素抵抗与脑血管病的关系 Relationship between Central Insulin Resistance and Cerebrovascular Disease

Abstract

中枢胰岛素参与大脑的多种生理功能，对多种行为和代谢产生影响。中枢胰岛素抵抗的定义是脑细胞不能对胰岛素作出反应。胰岛素受体表达下调、胰岛素受体不能结合胰岛素以及胰岛素信号级联错误激活等原因都有可能导致中枢胰岛素抵抗。中枢胰岛素抵抗与脑血管病有着密切的关系。通过高胰岛素-正葡萄糖钳夹结合影像技术、经鼻给药、丝氨酸磷酸化与总磷酸化胰岛素受体底物比率和测定神经源性血浆外泌体中胰岛素受体底物1的水平及其磷酸化状态等方法可以对中枢胰岛素抵抗进行评估。探索中枢胰岛素抵抗机制与脑血管病的关系将有助于为脑血管病的治疗提供新的方向和靶点。 Abstract: Central insulin is involved in a variety of physiological functions of the brain and affects a variety of behaviors and metabolism. Central insulin resistance is defined as the inability of brain cells to respond to insulin. Central insulin resistance may be caused by down-regulation of insulin receptor expression, failure of insulin receptor to bind insulin, or incorrect activation of insulin signal cascade. There is a close relationship between central insulin resistance and cerebrovascular disease. Central insulin resistance can be assessed by hyperinsulinemic euglycemic clamp combined imaging technology, intranasal administration, ratio of serine phosphorylation to total phosphorylated insulin receptor substrates and determinating IRS-1 level and its phosphorylation status in neurogenic plasma exosomes. Exploring the relationship between central insulin resistance and cerebrovascular disease will help to provide new directions and targets for treatment of cerebrovascular diseases.

Keywords

• 胰岛素
• 中枢胰岛素抵抗
• 脑血管病
• insulin
• central insulin resistance
• cerebrovascular disease