В мире научных открытий (Jul 2018)
EVALUATION OF EFFECTIVENESS OF HALOCYNTHIA AURANTIUM EXTRACT AT EXPERIMENTAL RAY IMPACT
Abstract
The effect of the extract from the marine hydrobiont Halocynthia aurantium (EA) under radiation exposure was studied. EA contains a complex of biologically active substances and has the ability to increase the nonspecific resistance of the organism to the action of a number of extreme damaging factors. The object of the study was the BALB/с mice subjected to γ-irradiation with low-power radiation. The aim of the work was to evaluate the therapeutic effect of EA on the post-radiation dynamics of peripheral blood parameters and bone marrow cellularity (dose 5 Gy) and on the outcome of radiation damage (dose 13 Gy). EA animals were received daily throughout the experiment, starting on the day of irradiation termination. The method of taking the material and analyzing elements of peripheral blood and bone marrow is standard. There was shown that in the early periods after irradiation, a sharp decrease in the total number of peripheral blood leukocytes and nucleated cells in the bone marrow was observed. The daily use of EA contributed to the acceleration of bone marrow cell repair and an increase in the total number of leukocytes and platelets in the peripheral blood. It can be concluded that the use of EA after radiation exposure has significantly increased the probability of a favorable outcome of acute radiation sickness at a dose of 5 Gy and to facilitate its course.
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