Transcriptional reprogramming of skeletal muscle stem cells by the niche environment

Felicia Lazure; Rick Farouni; Korin Sahinyan; Darren M. Blackburn; Aldo Hernández-Corchado; Gabrielle Perron; Tianyuan Lu; Adrien Osakwe; Jiannis Ragoussis; Colin Crist; Theodore J. Perkins; Arezu Jahani-Asl; Hamed S. Najafabadi; Vahab D. Soleimani

doi:10.1038/s41467-023-36265-x

Nature Communications (Feb 2023)

Transcriptional reprogramming of skeletal muscle stem cells by the niche environment

Felicia Lazure,
Rick Farouni,
Korin Sahinyan,
Darren M. Blackburn,
Aldo Hernández-Corchado,
Gabrielle Perron,
Tianyuan Lu,
Adrien Osakwe,
Jiannis Ragoussis,
Colin Crist,
Theodore J. Perkins,
Arezu Jahani-Asl,
Hamed S. Najafabadi,
Vahab D. Soleimani

Affiliations

Felicia Lazure: Department of Human Genetics, McGill University, 3640 rue University
Rick Farouni: Department of Human Genetics, McGill University, 3640 rue University
Korin Sahinyan: Department of Human Genetics, McGill University, 3640 rue University
Darren M. Blackburn: Department of Human Genetics, McGill University, 3640 rue University
Aldo Hernández-Corchado: Department of Human Genetics, McGill University, 3640 rue University
Gabrielle Perron: Department of Human Genetics, McGill University, 3640 rue University
Tianyuan Lu: Lady Davis Institute for Medical Research, Jewish General Hospital, 3755 Chemin de la Côte-Sainte-Catherine
Adrien Osakwe: Quantitative Life Sciences, McGill University
Jiannis Ragoussis: Department of Human Genetics, McGill University, 3640 rue University
Colin Crist: Department of Human Genetics, McGill University, 3640 rue University
Theodore J. Perkins: Sprott Center for Stem Cell Research, Ottawa Hospital Research Institute
Arezu Jahani-Asl: Department of Cellular and Molecular Medicine and University of Ottawa Brain and Mind Research Institute, University of Ottawa
Hamed S. Najafabadi: Department of Human Genetics, McGill University, 3640 rue University
Vahab D. Soleimani: Department of Human Genetics, McGill University, 3640 rue University

DOI: https://doi.org/10.1038/s41467-023-36265-x
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 16

Abstract

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Aging leads to significant alteration in the gene expression of muscle stem cells. In vivo exposure of muscle stem cells from aged mice to a young niche environment restores the expression of a significant portion of age-altered genes in mice.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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