Nature Communications (Mar 2021)
PGC1/PPAR drive cardiomyocyte maturation at single cell level via YAP1 and SF3B2
- Sean A. Murphy,
- Matthew Miyamoto,
- Anaïs Kervadec,
- Suraj Kannan,
- Emmanouil Tampakakis,
- Sandeep Kambhampati,
- Brian Leei Lin,
- Sam Paek,
- Peter Andersen,
- Dong-Ik Lee,
- Renjun Zhu,
- Steven S. An,
- David A. Kass,
- Hideki Uosaki,
- Alexandre R. Colas,
- Chulan Kwon
Affiliations
- Sean A. Murphy
- Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine
- Matthew Miyamoto
- Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine
- Anaïs Kervadec
- Sanford Burnham Prebys Medical Discovery Institute
- Suraj Kannan
- Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine
- Emmanouil Tampakakis
- Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine
- Sandeep Kambhampati
- Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine
- Brian Leei Lin
- Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine
- Sam Paek
- Rutgers Institute for Translational Medicine and Science
- Peter Andersen
- Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine
- Dong-Ik Lee
- Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine
- Renjun Zhu
- Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine
- Steven S. An
- Rutgers Institute for Translational Medicine and Science
- David A. Kass
- Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine
- Hideki Uosaki
- Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine
- Alexandre R. Colas
- Sanford Burnham Prebys Medical Discovery Institute
- Chulan Kwon
- Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-021-21957-z
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 12
Abstract
Cardiomyocyte maturation and the acquisition of phenotypes is poorly understood at the single cell level. Here, the authors analyse the transcriptome of single cells from neonatal to adult heart and reveal that peroxisome proliferator-activated receptor coactivator-1 mediates the phenotypic shift.
