Lipids in Health and Disease (Nov 2012)

eNOS genotype modifies the effect of leisure-time physical activity on serum triglyceride levels in a Japanese population

  • Higashibata Takahiro,
  • Hamajima Nobuyuki,
  • Naito Mariko,
  • Kawai Sayo,
  • Yin Guang,
  • Suzuki Sadao,
  • Kita Yoshikuni,
  • Niimura Hideshi,
  • Imaizumi Takeshi,
  • Ohnaka Keizo,
  • Arisawa Kokichi,
  • Shigeta Masako,
  • Ito Hidemi,
  • Mikami Haruo,
  • Kubo Michiaki,
  • Tanaka Hideo,
  • Wakai Kenji

DOI
https://doi.org/10.1186/1476-511X-11-150
Journal volume & issue
Vol. 11, no. 1
p. 150

Abstract

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Abstract Background Nitric oxide is a key molecule not only in the cardiovascular system, but also in the metabolic-endocrine system. The purpose of this study was to examine possible associations of the NOS3 T-786C polymorphism (rs2070744) with serum lipid levels on the basis of lifestyle factors for tailoring prevention of dyslipidemia. Methods For this cross-sectional study, a total of 2226 subjects aged 35 to 69 years (1084 men and 1142 women) were selected from Japanese participants in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. They were recruited in eight areas throughout Japan between February 2004 and November 2008. Results In a stratified analysis by leisure-time physical activity, the likelihood of hypertriglyceridemia (serum triglyceride levels ≥ 150 mg/dL) among subjects with the C allele was significantly lower than those without it in the active group (OR = 0.43, 95% CI = 0.22-0.84 in the fasting group), but not in the sedentary group. A gene-environment interaction between the T-786C polymorphism and leisure-time physical activity for hypertriglyceridemia was significant (P = 0.007 in the fasting group). Additionally, serum triglyceride levels (mean ± SD) across leisure-time physical activity classes decreased significantly only in the TC + CC genotype group (111 ± 60 mg/dL for sedentary, 95 ± 48 mg/dL for moderately active, 88 ± 44 mg/dL for very active, P for trend = 0.008 in the fasting group), but not in the TT genotype group. Total cholesterol, high-density lipoprotein (HDL) cholesterol, and non-HDL cholesterol levels had no significant association with the polymorphism. Conclusions This study suggests that the NOS3 T-786C polymorphism modifies the effect of leisure-time physical activity on serum triglyceride levels.

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