Synthesis and biological evaluation of new benzothiazoles as antimicrobial agents

Abstract

A new series of hydrazide derivatives were synthesized, characterized, and biologically evaluated. The reaction of 2-chloro benzo[d]thiazole 1, with ethyl 2-(piperazin-1-yl) acetate 2, led to the formation of ethyl 2-(4-(benzo[d]thiazol-2-yl)piperazin-1-yl)acetate 3. The reaction of compound 3 with excess amount of hydrazine hydrate gave 2-(4-(benzo[d]thiazol-2-yl) piperazin-1-yl) acetohydrazide 4. Hydrazide derivatives 5(a–j) were prepared by the reaction of compound 4 with the appropriate acid chloride. The in vitro antibacterial activity of compounds 3, 4, 5a, and 5b were screened against Staphylococcus aureus, Escherichia coli, and Candida albicans bacteria, no activity has been witnessed.

Keywords

• Hydrazide
• Benzothiazole
• Piperazine
• Antibacterial
• Staphylococcus aureus
• Escherichia coli
• Candida albicans