Advancement in research on genes associated with fetal congenital heart disease (CHD) and diagnostic testing methods

Abstract

Introduction: Congenital heart disease (CHD) is one of the most common congenital malformations, and is a polygenic disease related to some major genes and involved in environmental factors. With the progress of science and technology, the progress was both in the studies of genetic patterns and testing methods. Understanding how each gene participates in normal and pathological anatomy is an important goal of CHD research. We reviewed the development of testing methods and CHD-related genes, to provide some enlightenment for the CHD prenatal diagnosis and hope to realize the intervention and treatment on the gene level of CHD in the future.

Keywords

• Congenital heart disease
• Single cell RNA Sequencing
• Genetic factors
• Gene network