Nature Communications (Apr 2018)
Reduced oxidative capacity in macrophages results in systemic insulin resistance
- Saet-Byel Jung,
- Min Jeong Choi,
- Dongryeol Ryu,
- Hyon-Seung Yi,
- Seong Eun Lee,
- Joon Young Chang,
- Hyo Kyun Chung,
- Yong Kyung Kim,
- Seul Gi Kang,
- Ju Hee Lee,
- Koon Soon Kim,
- Hyun Jin Kim,
- Cuk-Seong Kim,
- Chul-Ho Lee,
- Robert W. Williams,
- Hail Kim,
- Heung Kyu Lee,
- Johan Auwerx,
- Minho Shong
Affiliations
- Saet-Byel Jung
- Research Center for Endocrine and Metabolic Diseases, Department of Medical Science, School of Medicine, Chungnam National University
- Min Jeong Choi
- Research Center for Endocrine and Metabolic Diseases, Department of Medical Science, School of Medicine, Chungnam National University
- Dongryeol Ryu
- Laboratory for Integrative and Systems Physiology, Institute of Bioengineering, École Polytechnique Fédérale de Lausanne
- Hyon-Seung Yi
- Department of Internal Medicine, Chungnam National University Hospital
- Seong Eun Lee
- Research Center for Endocrine and Metabolic Diseases, Department of Medical Science, School of Medicine, Chungnam National University
- Joon Young Chang
- Research Center for Endocrine and Metabolic Diseases, Department of Medical Science, School of Medicine, Chungnam National University
- Hyo Kyun Chung
- Research Center for Endocrine and Metabolic Diseases, Department of Medical Science, School of Medicine, Chungnam National University
- Yong Kyung Kim
- Research Center for Endocrine and Metabolic Diseases, Department of Medical Science, School of Medicine, Chungnam National University
- Seul Gi Kang
- Research Center for Endocrine and Metabolic Diseases, Department of Medical Science, School of Medicine, Chungnam National University
- Ju Hee Lee
- Department of Internal Medicine, Chungnam National University Hospital
- Koon Soon Kim
- Research Center for Endocrine and Metabolic Diseases, Department of Medical Science, School of Medicine, Chungnam National University
- Hyun Jin Kim
- Department of Internal Medicine, Chungnam National University Hospital
- Cuk-Seong Kim
- Department of Physiology, Department of Medical Science, School of Medicine, Chungnam National University
- Chul-Ho Lee
- Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology
- Robert W. Williams
- Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center
- Hail Kim
- Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology
- Heung Kyu Lee
- Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology
- Johan Auwerx
- Laboratory for Integrative and Systems Physiology, Institute of Bioengineering, École Polytechnique Fédérale de Lausanne
- Minho Shong
- Research Center for Endocrine and Metabolic Diseases, Department of Medical Science, School of Medicine, Chungnam National University
- DOI
- https://doi.org/10.1038/s41467-018-03998-z
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 15
Abstract
M1-like polarization of macrophages is thought to control adipose inflammation and associated insulin resistance and metabolic syndrome. Here the authors show that macrophage-specific deletion of the OxPhos-related gene Crif1 results in an M1-like phenotype in mice, and that the effects can be reversed by recombinant GDF15.
