Pulmonary Circulation (Nov 2020)
Transcriptomic profiles in pulmonary arterial hypertension associate with disease severity and identify novel candidate genes
- Casey E. Romanoski,
- Xinshuai Qi,
- Shreya Sangam,
- Rebecca R. Vanderpool,
- Robert S. Stearman,
- Austin Conklin,
- Manuel Gonzalez-Garay,
- Franz Rischard,
- Ramon J. Ayon,
- Jian Wang,
- Tatum Simonson,
- Aleksandra Babicheva,
- Yinan Shi,
- Haiyang Tang,
- Ayako Makino,
- Yogendra Kanthi,
- Mark W. Geraci,
- Joe G.N. Garcia,
- Jason X.-J. Yuan,
- Ankit A. Desai
Affiliations
- Casey E. Romanoski
- Department of Cellular and Molecular Medicine, College of Medicine, , Tucson, AZ, USA
- Xinshuai Qi
- Department of Medicine, College of Medicine, , Tucson, AZ, USA
- Shreya Sangam
- Department of Medicine, Indiana University, Indianapolis, IN, USA
- Rebecca R. Vanderpool
- Department of Medicine, College of Medicine, , Tucson, AZ, USA
- Robert S. Stearman
- Department of Medicine, Indiana University, Indianapolis, IN, USA
- Austin Conklin
- Department of Cellular and Molecular Medicine, College of Medicine, , Tucson, AZ, USA
- Manuel Gonzalez-Garay
- Department of Medicine, College of Medicine, , Tucson, AZ, USA
- Franz Rischard
- Department of Medicine, College of Medicine, , Tucson, AZ, USA
- Ramon J. Ayon
- Department of Medicine, College of Medicine, , Tucson, AZ, USA
- Jian Wang
- Department of Medicine, University of California, San Diego, La Jolla, CA, USA
- Tatum Simonson
- Department of Medicine, University of California, San Diego, La Jolla, CA, USA
- Aleksandra Babicheva
- Department of Medicine, University of California, San Diego, La Jolla, CA, USA
- Yinan Shi
- Department of Medicine, Indiana University, Indianapolis, IN, USA
- Haiyang Tang
- State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Disease, , Guangzhou, China
- Ayako Makino
- Department of Physiology, College of Medicine, , Tucson, AZ, USA
- Yogendra Kanthi
- Division of Cardiovascular Medicine, Department of Internal Medicine, , Ann Arbor, Michigan, USA
- Mark W. Geraci
- Department of Medicine, Indiana University, Indianapolis, IN, USA
- Joe G.N. Garcia
- Department of Physiology, College of Medicine, , Tucson, AZ, USA
- Jason X.-J. Yuan
- Department of Physiology, College of Medicine, , Tucson, AZ, USA
- Ankit A. Desai
- Department of Medicine, Indiana University, Indianapolis, IN, USA
- DOI
- https://doi.org/10.1177/2045894020968531
- Journal volume & issue
-
Vol. 10
Abstract
Using RNAseq, we identified a 61 gene-based circulating transcriptomic profile most correlated with four indices of pulmonary arterial hypertension severity. In an independent dataset, 13/61 (21%) genes were differentially expressed in lung tissues of pulmonary arterial hypertension cases versus controls, highlighting potentially novel candidate genes involved in pulmonary arterial hypertension development.
