Nature Communications (Jan 2018)

Molecular snapshots of APE1 proofreading mismatches and removing DNA damage

  • Amy M. Whitaker,
  • Tony S. Flynn,
  • Bret D. Freudenthal

DOI
https://doi.org/10.1038/s41467-017-02175-y
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 11

Abstract

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The essential DNA repair enzyme apurinic/apyrimidinic endonuclease 1 (APE1) has both endonuclease and exonuclease activities. Here, the authors present DNA bound human APE1 crystal structures which give insights into its exonuclease mechanism.