Nature Communications (Jan 2018)
Molecular snapshots of APE1 proofreading mismatches and removing DNA damage
Abstract
The essential DNA repair enzyme apurinic/apyrimidinic endonuclease 1 (APE1) has both endonuclease and exonuclease activities. Here, the authors present DNA bound human APE1 crystal structures which give insights into its exonuclease mechanism.